Induced pluripotent stem cells: Difference between revisions

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==Introduction==
==Introduction==
'''Induced pluripotent stem cells''' ('''iPS''' cells) are a class of [[stem cells]] that are artificially derived from differentiated embryonic or adult tissues.  Therapeutically, iPS cells hold the potential to be used to treat a patient with their own cells (i.e. bone marrow transplant, spinal cord injury repair).
'''Induced pluripotent stem cells''' ('''iPS''' cells) are a class of [[stem cells]] that are artificially derived from differentiated embryonic or adult tissues.  Therapeutically, iPS cells hold the potential to be used to treat a patient with their own cells (i.e. bone marrow transplant, spinal cord injury repair).
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==references==
==references==
1.  Takahashi K, Yamanaka S.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.  Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10.  PMID: 16904174 [PubMed - indexed for MEDLINE]
1.  Takahashi K, Yamanaka S.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.  Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10.  PMID: 16904174 [PubMed - indexed for MEDLINE]
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Revision as of 18:28, 3 November 2007

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Introduction

Induced pluripotent stem cells (iPS cells) are a class of stem cells that are artificially derived from differentiated embryonic or adult tissues. Therapeutically, iPS cells hold the potential to be used to treat a patient with their own cells (i.e. bone marrow transplant, spinal cord injury repair).

Multiple strategies to generate iPS cells are being developed.

  • Somatic cell nuclear transfer
  • Embryonic stem cell fusion
  • Nuclear Reprogramming

Nuclear Reprogramming

Based on previous studies, one research group set out to determine which genes are required to be expressed in order to generate/maintain embryonic stem cells.1 In a series of experiments it was determined that 4 factors are required to cause mouse fibroblasts to "dedifferentiate" into a stem-cell like state.

  • Sox2
  • Klf4
  • Oct3/4
  • c-myc

references

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10. PMID: 16904174 [PubMed - indexed for MEDLINE]