Mevalonate: Difference between revisions

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Mevalonate.

Mevalonate is a key chemical precursor in the biosynthesis of cholesterol. The statin drugs used to lower cholesterol are HMG-CoA reductase inhibitors that work by inhibiting the synthesis of mevalonate from the reduction of 3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA).

(CC) Image: David E. Volk
Biosynthesis of mevalonate from HMG CoA.

Its IUPAC chemical name is (3R)-3,5-dihydroxy-3-methylpentanoic acid and its chemical formula is C₆H₁₂O4 in the protonated state.

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	[[Image:Mevalonate synthesis.jpg\|left~~\|thumb~~\|250px\|~~{{#ifexist:Template:Mevalonate synthesis.jpg/credit\|{{Mevalonate synthesis.jpg/credit}}<br/>\|}}~~Biosynthesis of mevalonate from HMG CoA.]]		{{Image\|Mevalonate synthesis.jpg\|left\|250px\|Biosynthesis of mevalonate from HMG CoA.}}

	Its IUPAC chemical name is (3R)-3,5-dihydroxy-3-methylpentanoic acid and its chemical formula is C<sub>6</sub>H<sub>12</sub>O<small>4</small> in the protonated state.		Its IUPAC chemical name is (3R)-3,5-dihydroxy-3-methylpentanoic acid and its chemical formula is C<sub>6</sub>H<sub>12</sub>O<small>4</small> in the protonated state.