Stavudine: Difference between revisions

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imported>David E. Volk
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[[Image:Stavudine structure.jpg|right|thumb|150px|{{#ifexist:Template:Stavudine structure.jpg/credit|{{Stavudine structure.jpg/credit}}<br/>|}}Stavudine]]
{{Chem infobox
|align=right
|image=[[Image:Stavudine structure.jpg|center|thumb|200px]]
|width=200px
|molname=stavudine
|synonyms=  '''Zerit®'''
|molformula= C<sub>35</sub>H<sub>38</sub>C<sub>l2</sub>N<sub>8</sub>O<sub>4</sub>
|molmass= 224.2133
|uses=HIV/AIDS
|properties=thymidine-like RT inhibitor
|hazards=see Drug interactions
|iupac= see Chemistry
|casnumber=3056-17-5
}}


'''Stavudine''' is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythimidine) , [[antiviral drug]] that inhibits [[reverse transcriptase]] and is used to treat against [[HIV]]/[[AIDS]] sold under the brand name '''Zerit®'''.  It is in the drug class [[nucleoside reverse transcriptase inhibitor]] (NRTI).  The phosphorylated form is the active compound that competes with [[deoxythimidine]] triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group.
 
'''Stavudine''' is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythymidine) , [[antiviral drug]] that inhibits [[reverse transcriptase]] and is used to treat against [[HIV]]/[[AIDS]] sold under the brand name '''Zerit®'''.  It is in the drug class [[nucleoside reverse transcriptase inhibitor]] (NRTI).  The phosphorylated form is the active compound that competes with [[deoxythymidine]] triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group.
 
 
== Chemistry ==
The IUPAC chemical name for stavudine is 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione, and it has a molecular formula C<sub>10</sub>H<sub>12</sub>N<sub>2</sub>O<sub>4</sub>, giving it a molecular mass of 224.2133 g/mol.


== External links ==
== External links ==

Revision as of 13:50, 24 March 2008

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Stavudine structure.jpg
stavudine
IUPAC name: see Chemistry
Synonyms: Zerit®
Formula: C35H38Cl2N8O4
 Uses: HIV/AIDS
 Properties: thymidine-like RT inhibitor
 Hazards: see Drug interactions
Mass (g/mol): CAS #:
224.2133 3056-17-5



Stavudine is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythymidine) , antiviral drug that inhibits reverse transcriptase and is used to treat against HIV/AIDS sold under the brand name Zerit®. It is in the drug class nucleoside reverse transcriptase inhibitor (NRTI). The phosphorylated form is the active compound that competes with deoxythymidine triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group.


Chemistry

The IUPAC chemical name for stavudine is 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione, and it has a molecular formula C10H12N2O4, giving it a molecular mass of 224.2133 g/mol.

External links

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