QT interval: Difference between revisions
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A prolonged QT internal may lead to [[Torsades de pointes]]. Drugs may prolong the [[QT interval]].<ref name="pmid14999113">{{cite journal |author=Roden DM |title=Drug-induced prolongation of the QT interval |journal=N. Engl. J. Med. |volume=350 |issue=10 |pages=1013–22 |year=2004 |month=March |pmid=14999113 |doi=10.1056/NEJMra032426 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=14999113&promo=ONFLNS19 |issn=}}</ref> A list of these drugs is available at the [http://torsades.org/medical-pros/drug-lists/bycategory.cfm Arizona Center for Education & Research on Therapeutics]. | A prolonged QT internal may lead to [[Torsades de pointes]]. Drugs may prolong the [[QT interval]].<ref name="pmid14999113">{{cite journal |author=Roden DM |title=Drug-induced prolongation of the QT interval |journal=N. Engl. J. Med. |volume=350 |issue=10 |pages=1013–22 |year=2004 |month=March |pmid=14999113 |doi=10.1056/NEJMra032426 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=14999113&promo=ONFLNS19 |issn=}}</ref> A list of these drugs is available at the [http://torsades.org/medical-pros/drug-lists/bycategory.cfm Arizona Center for Education & Research on Therapeutics]. | ||
==Congenital Long QT Syndrome== | |||
===Andersen Syndrome=== | |||
Andersen Syndrome is a "form of inherited long QT syndrome (or LQT7) that is characterized by a triad of potassium-sensitive periodic paralysis, ventricular ectopic beats, and abnormal features such as short stature, low-set ears, and scoliosis. It results from mutations of KCNJ2 gene which encodes a channel protein ([[inward rectifier potassium channel]]s) that regulates resting membrane potential."<ref>{{MeSH|Andersen Syndrome}}</ref><ref>{{OMIM|170390}}</ref> | |||
===Jervell-Lange Nielsen Syndrome=== | |||
Jervell-Lange Nielsen Syndrome is a "form of long QT syndrome that is associated with congenital deafness. It is characterized by abnormal cardioelectrophysiology involving the [[voltage-gated potassium channel]]. It results from mutation of KCNQ1 gene (Subtype 1 or JLN1) or the KCNE1 gene (Subtype 2 or JLN2).."<ref>{{MeSH|Jervell-Lange Nielsen Syndrome}}</ref><ref>{{OMIM|220400}}</ref><ref>{{OMIM|612347}}</ref> | |||
===Romano-Ward Syndrome=== | |||
Romano-Ward Syndrome (LQT1) is a "form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the [[voltage-gated potassium channel]]."<ref>{{MeSH|Romano-Ward Syndrome}}</ref><ref>{{OMIM|192500}</ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 21:39, 12 January 2009
In cardiology and the electrocardiogram, the QT interval is the time from the start of the Q wave and the end of the T wave.
To correct the QT interval for heart rate:
Normal values for the corrected QT interval are between 0.36 and 0.44 seconds.
A prolonged QT internal may lead to Torsades de pointes. Drugs may prolong the QT interval.[1] A list of these drugs is available at the Arizona Center for Education & Research on Therapeutics.
Congenital Long QT Syndrome
Andersen Syndrome
Andersen Syndrome is a "form of inherited long QT syndrome (or LQT7) that is characterized by a triad of potassium-sensitive periodic paralysis, ventricular ectopic beats, and abnormal features such as short stature, low-set ears, and scoliosis. It results from mutations of KCNJ2 gene which encodes a channel protein (inward rectifier potassium channels) that regulates resting membrane potential."[2][3]
Jervell-Lange Nielsen Syndrome
Jervell-Lange Nielsen Syndrome is a "form of long QT syndrome that is associated with congenital deafness. It is characterized by abnormal cardioelectrophysiology involving the voltage-gated potassium channel. It results from mutation of KCNQ1 gene (Subtype 1 or JLN1) or the KCNE1 gene (Subtype 2 or JLN2).."[4][5][6]
Romano-Ward Syndrome
Romano-Ward Syndrome (LQT1) is a "form of long QT syndrome that is without congenital deafness. It is caused by mutation of the KCNQ1 gene which encodes a protein in the voltage-gated potassium channel."[7][8]
References
- ↑ Roden DM (March 2004). "Drug-induced prolongation of the QT interval". N. Engl. J. Med. 350 (10): 1013–22. DOI:10.1056/NEJMra032426. PMID 14999113. Research Blogging.
- ↑ Anonymous (2024), Andersen Syndrome (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 170390. World Wide Web URL: http://omim.org/.
- ↑ Anonymous (2024), Jervell-Lange Nielsen Syndrome (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 220400. World Wide Web URL: http://omim.org/.
- ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 612347. World Wide Web URL: http://omim.org/.
- ↑ Anonymous (2024), Romano-Ward Syndrome (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ {{OMIM|192500}