Selective serotonin uptake inhibitor: Difference between revisions
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imported>Robert Badgett (New page: In medicine, '''serotonin uptake inhibitors''' are second-generation antidepressants that potentiate the effect of serotonin by blocking its uptake from the synaptic cleft. ==...) |
imported>Robert Badgett |
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* [[Duloxetine]]. Inhibits [[cytochrome P-450 CYP2D6]]. | * [[Duloxetine]]. Inhibits [[cytochrome P-450 CYP2D6]]. | ||
* [[Fluoxetine]] (generic). Inhibits [[cytochrome P-450 CYP2D6]]. | * [[Fluoxetine]] (generic). Inhibits [[cytochrome P-450 CYP2D6]]. | ||
* [[Paroxetine]] (generic). Inhibits [[cytochrome P-450 CYP2D6]]. May increase death from [[breast cancer]] among women taking [[tamoxifen]].<ref>{{Cite journal | * [[Paroxetine]] (generic). Inhibits [[cytochrome P-450 CYP2D6]]. May increase death from [[breast cancer]] among women taking [[tamoxifen]] due to inhibiting metabolism of [[tamoxifen]] to itc active metabolite by [[cytochrome P-450 CYP2D6]].<ref>{{Cite journal | ||
| doi = 10.1136/bmj.c693 | | doi = 10.1136/bmj.c693 | volume = 340 | issue = feb08_1 | pages = c693 | last = Kelly | first = Catherine M | coauthors = David N Juurlink, Tara Gomes, Minh Duong-Hua, Kathleen I Pritchard, Peter C Austin, Lawrence F Paszat | title = Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study | ||
| volume = 340 | | journal = BMJ | accessdate = 2010-02-10 | date = 2010-02-08 | url = http://www.bmj.com/cgi/content/abstract/340/feb08_1/c693 }}</ref> | ||
| issue = feb08_1 | |||
| pages = c693 | |||
| last = Kelly | |||
| first = Catherine M | |||
| coauthors = David N Juurlink, Tara Gomes, Minh Duong-Hua, Kathleen I Pritchard, Peter C Austin, Lawrence F Paszat | |||
| title = Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study | |||
| journal = BMJ | |||
| accessdate = 2010-02-10 | |||
| date = 2010-02-08 | |||
| url = http://www.bmj.com/cgi/content/abstract/340/feb08_1/c693 | |||
}}</ref> | |||
* [[Sertraline]] (generic) | * [[Sertraline]] (generic) | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 09:33, 10 February 2010
In medicine, serotonin uptake inhibitors are second-generation antidepressants that potentiate the effect of serotonin by blocking its uptake from the synaptic cleft.
Examples
- Citalopram (generic). Can be combined with bupropion.
- Duloxetine. Inhibits cytochrome P-450 CYP2D6.
- Fluoxetine (generic). Inhibits cytochrome P-450 CYP2D6.
- Paroxetine (generic). Inhibits cytochrome P-450 CYP2D6. May increase death from breast cancer among women taking tamoxifen due to inhibiting metabolism of tamoxifen to itc active metabolite by cytochrome P-450 CYP2D6.[1]
- Sertraline (generic)
References
- ↑ Kelly, Catherine M; David N Juurlink, Tara Gomes, Minh Duong-Hua, Kathleen I Pritchard, Peter C Austin, Lawrence F Paszat (2010-02-08). "Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study". BMJ 340 (feb08_1): c693. DOI:10.1136/bmj.c693. Retrieved on 2010-02-10. Research Blogging.