Mirtazapine: Difference between revisions
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Compared to other [[antidepressant]]s, a second [[meta-analysis]] found that mirtazapine was "more likely to cause weight gain or increased appetite and somnolence than SSRIs but less likely to cause nausea or vomiting and sexual dysfunction."<ref name="pmid22161405">{{cite journal| author=Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R et al.| title=Mirtazapine versus other antidepressive agents for depression. | journal=Cochrane Database Syst Rev | year= 2011 | volume= 12 | issue= | pages= CD006528 | pmid=22161405 | doi=10.1002/14651858.CD006528.pub2 | pmc= | url= }} </ref> | Compared to other [[antidepressant]]s, a second [[meta-analysis]] found that mirtazapine was "more likely to cause weight gain or increased appetite and somnolence than SSRIs but less likely to cause nausea or vomiting and sexual dysfunction."<ref name="pmid22161405">{{cite journal| author=Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R et al.| title=Mirtazapine versus other antidepressive agents for depression. | journal=Cochrane Database Syst Rev | year= 2011 | volume= 12 | issue= | pages= CD006528 | pmid=22161405 | doi=10.1002/14651858.CD006528.pub2 | pmc= | url= }} </ref> | ||
Mirtazapine can cause elevated [[liver function test]]s and [[neutropenia]]<ref name="pmid8930008">{{cite journal| author=Montgomery SA| title=Safety of mirtazapine: a review. | journal=Int Clin Psychopharmacol | year= 1995 | volume= 10 Suppl 4 | issue= | pages= 37-45 | pmid=8930008 | doi= | pmc= | url= }} </ref> | |||
==External links== | ==External links== | ||
Revision as of 10:22, 27 December 2011
Mirtazapine is a second-generation antidepressant agent. Mirtazapine is also classified as a tricyclic antidepressant by the National Library of Medicine in the United States.[1]
History
Remeron brand of mirtazapine was approved for Organon USA by the Food and Drug Administration in the United States with a New Drug Application (NDA) in 1996.[2] A generic version with a AB Therapeutic Equivalence Code was approved for Glenmark Generics with a Abbreviated New Drug Application (ANDA) in 2004.[3]
Effectiveness
"The clinical response of our patients underscores the usefulness of mirtazapine in the treatment of the comorbid symptoms of weight loss, insomnia, and anxiety". [4]
Pharmacology
Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA).[5]
Administration
Distribution
Metabolism
Excretion
Toxicity
Drug toxicity is similar to tricyclic antidepressants. Amitriptyline, mirtazapine, and paroxetine may case more weight gain than other antidepressants according to a meta-analysis.[6]
Compared to other antidepressants, a second meta-analysis found that mirtazapine was "more likely to cause weight gain or increased appetite and somnolence than SSRIs but less likely to cause nausea or vomiting and sexual dysfunction."[5]
Mirtazapine can cause elevated liver function tests and neutropenia[7]
External links
The most up-to-date information about Mirtazapine and other drugs can be found at the following sites.
- Mirtazapine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Mirtazapine - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Mirtazapine - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Mirtazapine (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anonymous. Drugs@FDA for FDA Application No. 020415. U S Food and Drug Administration
- ↑ Anonymous. Drugs@FDA for FDA Application No. 076119. U S Food and Drug Administration
- ↑ Raji MA, Brady SR (2001). "Mirtazapine for treatment of depression and comorbidities in Alzheimer disease.". Ann Pharmacother 35 (9): 1024-7. PMID 11573849. [e]
- ↑ 5.0 5.1 Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R et al. (2011). "Mirtazapine versus other antidepressive agents for depression.". Cochrane Database Syst Rev 12: CD006528. DOI:10.1002/14651858.CD006528.pub2. PMID 22161405. Research Blogging.
- ↑ Serretti A, Mandelli L (2010). "Antidepressants and body weight: a comprehensive review and meta-analysis.". J Clin Psychiatry 71 (10): 1259-72. DOI:10.4088/JCP.09r05346blu. PMID 21062615. Research Blogging.
- ↑ Montgomery SA (1995). "Safety of mirtazapine: a review.". Int Clin Psychopharmacol 10 Suppl 4: 37-45. PMID 8930008. [e]