Anthraquinone: Difference between revisions

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imported>Howard C. Berkowitz
(New page: {{subpages}} left|thumb|200px|Anthraquinone molecular structure '''Anthraquinone''' is the class-defining compound for a number of naturally-occurring plant pig...)
 
imported>Howard C. Berkowitz
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  | url = http://www.ncbi.nlm.nih.gov/pubmed/8022857}}</ref>
  | url = http://www.ncbi.nlm.nih.gov/pubmed/8022857}}</ref>


The plant ''[[Rheum palmatum]]'', called [[Indian rhubarb]] in North America and also used in [[traditional Chinese medicine]] is rich in anthraquinones. Indian rhubarb is a constituent of the herbal cancer treatment, [[Essiac]]. Extracts of the plant have shown activity against [[hepatitis B virus]].<ref>{{citation
The plant ''[[Rheum palmatum]]'', called [[Indian rhubarb]] in North America and also used in [[traditional Chinese medicine]] is rich in anthraquinones.  
| title = (Abstract) Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L. ethanol extract.
| journal = Chemotherapy | year =  2007 | volume =  53 |issue =5 | pages = 320-6 
| author = Li Z; Li LJ; Sun Y; Li J
| url = http://www.medscape.com/medline/abstract/17785969
}}</ref>


Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of ''R. palmatum''. Activation of caspase-3, caspase-8, and caspase-9 is an important determinant of apoptotic death induced by aloe-emodin. These results suggest that aloe-emodin induces cell death in a human lung [[squamous cell carcinoma]] line, CH27, by the Bax and Fas death pathway.<ref>{{citation
Anthraquinone derivatives called sennosides are used as cathartics; they are the active principle in [[senna extract]].
| title = (Abstract) Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma
| journal = Eur J Pharmacol | year = 2001 | volume = 431 | issue = 3 | pages = 287-95
| author = Lee HZ; Hsu SL; Liu MC; Wu CH
| url = http://www.medscape.com/medline/abstract/11730720
}}</ref>


==References==
==References==
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Anthraquinone molecular structure

Anthraquinone is the class-defining compound for a number of naturally-occurring plant pigments. Anthraquinone itself has been associated with causing liver, bladder and kidney cancers, and other non-neoplastic disorders.[1]. It also, however, has been a starting point for developing antineoplastic agents, especially the anthracycline agents, of which doxorubricin (Adriamycin) is best known. [2]

The plant Rheum palmatum, called Indian rhubarb in North America and also used in traditional Chinese medicine is rich in anthraquinones.

Anthraquinone derivatives called sennosides are used as cathartics; they are the active principle in senna extract.

References