Polycythemia vera: Difference between revisions
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== JAK2 mutations == | == JAK2 mutations == | ||
<ref name= James> Mutations in the JAK2 gene, specifically at the V617F locus, give rise to [[myeloproliferative syndromes|myeloproliferative disorders]] such as [[essential thrombocythemia]] and [[polycythemia vera]] | <ref name= James> Mutations in the JAK2 gene</ref>, specifically at the V617F locus, give rise to [[myeloproliferative syndromes|myeloproliferative disorders]] such as [[essential thrombocythemia]] and [[polycythemia vera]]. | ||
Authors <ref name=Scott>reported</ref> that other mutations of the coding region of the JAK2 gene could create a polycythemia phenotype. | Authors <ref name=Scott>reported</ref> that other mutations of the coding region of the JAK2 gene could create a polycythemia phenotype. | ||
Revision as of 02:10, 12 February 2007
Clinical criteria
JAK2 mutations
[1], specifically at the V617F locus, give rise to myeloproliferative disorders such as essential thrombocythemia and polycythemia vera.
Authors [2] that other mutations of the coding region of the JAK2 gene could create a polycythemia phenotype.
[2]Scott, et al. New Engl J Med 356: 459-468 2007. [1]James, et al. Nature 434:1144-8 2005.