Doxycycline: Difference between revisions
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==Pharmacokinetics== | ==Pharmacokinetics== | ||
===Absorption=== | ===Absorption=== | ||
Immediate-release formulations of doxycycline, similar to tetracycline<ref name="pmid3838321">{{cite journal |author=Leyden JJ |title=Absorption of minocycline hydrochloride and tetracycline hydrochloride. Effect of food, milk, and iron |journal=J. Am. Acad. Dermatol. |volume=12 |issue=2 Pt 1 |pages=308–12 |year=1985 |pmid=3838321 |doi=}}</ref>, has absorption | Immediate-release formulations of doxycycline, similar to tetracycline<ref name="pmid3838321">{{cite journal |author=Leyden JJ |title=Absorption of minocycline hydrochloride and tetracycline hydrochloride. Effect of food, milk, and iron |journal=J. Am. Acad. Dermatol. |volume=12 |issue=2 Pt 1 |pages=308–12 |year=1985 |pmid=3838321 |doi=}}</ref>, has absorption reduced or delayed by milk.<ref name="pmid2767766">{{cite journal |author=Meyer FP, Specht H, Quednow B, Walther H |title=Influence of milk on the bioavailability of doxycycline--new aspects |journal=Infection |volume=17 |issue=4 |pages=245–6 |year=1989 |pmid=2767766 |doi=}}</ref> However, the milk interaction is much smaller for doxycycline and of uncertain importance.<ref name="pmid856000">{{cite journal |author=Welling PG, Koch PA, Lau CC, Craig WA |title=Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects |journal=Antimicrob. Agents Chemother. |volume=11 |issue=3 |pages=462–9 |year=1977 |pmid=856000 |doi=}}</ref> | ||
===Distribution=== | ===Distribution=== | ||
Revision as of 08:28, 9 November 2007
Doxycycline is "a synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria".[1]
Pharmacokinetics
Absorption
Immediate-release formulations of doxycycline, similar to tetracycline[2], has absorption reduced or delayed by milk.[3] However, the milk interaction is much smaller for doxycycline and of uncertain importance.[4]
Distribution
Metabolism
Excretion
Medical uses
References
- ↑ National Library of Medicine. Doxycycline. Retrieved on 2007-11-08.
- ↑ Leyden JJ (1985). "Absorption of minocycline hydrochloride and tetracycline hydrochloride. Effect of food, milk, and iron". J. Am. Acad. Dermatol. 12 (2 Pt 1): 308–12. PMID 3838321. [e]
- ↑ Meyer FP, Specht H, Quednow B, Walther H (1989). "Influence of milk on the bioavailability of doxycycline--new aspects". Infection 17 (4): 245–6. PMID 2767766. [e]
- ↑ Welling PG, Koch PA, Lau CC, Craig WA (1977). "Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects". Antimicrob. Agents Chemother. 11 (3): 462–9. PMID 856000. [e]