Cidofovir: Difference between revisions
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|properties=cytosine analog | |properties=cytosine analog | ||
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|iupac= see chemistry section | |iupac= see chemistry section | ||
|casnumber= 113852-37-2 | |casnumber= 113852-37-2 |
Revision as of 09:04, 22 March 2008
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cidofovir | |||||||
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Uses: | antiviral drug | ||||||
Properties: | cytosine analog | ||||||
Hazards: | renal failure | ||||||
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Cidofovir (CDV) is an antiviral drug used to treat herpes cytomegalovirus (CMV) retinitis associated with HIV/AIDS. It is an analog of the natural nucleoside cytosine used in DNA. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. Warning:Acute renal failure requiring dialysis and/or contributing to death have occured with as few as one or two doses of cidofovir.
Chemistry
Its chemical name is [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid and its chemical formula is C8H14N3O6P. It is sold under the brand names HPMPC and Vistide.
External Links
- Cidofovir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Template:MedMaster
- Template:DrugBank