Emtricitabine

(CC) Image: David E. Volk Emtricitabine
emtricitabine
IUPAC name: see chemistry section Synonyms: Coviracil®, Emtriva®, Racivir® Formula: C8H10FN3O3S
Uses:	HIV
Properties:	Reverse transcriptase inhibitor
Hazards:	see drug interactions
Mass (g/mol): CAS #: 247.2467 143491-57-0

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) antiviral drug used to treat HIV/AIDS. Emtricitabine is a synthetic analogue of cytidine and is similar in structure to the drugs zalcitabine and lamivudine. Once the drug in converted to the triphosphate form, it works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA, by competing with the natural DNA base deoxycytidine triphosphate (dCTP). Once it is incorporated into a growing viral DNA strand, it acts as a chain terminator because it lacks a 3'-hydroxy group needed for form a phosphodiester linkage to the next incoming DNA base. It is usually used in combination with other anti-HIV drugs.

Chemistry

It IUPAC chemical name is 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one and its chemical formula is C₈H₁₀FN₃O₃S. It is sold as a single drug under the trade names Coviracil®, Emtriva® and Racivir® and in combination with other antiviral drugs as Truvada® (with tenovir) and Sustiva® (with tenovir and efaverenz).

External links

• Emtricitabine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
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