Clotrimazole: Difference between revisions
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'''Clotrimazole''', also called clotrimazol and chlotrimazole, is | '''Clotrimazole''', also called clotrimazol and chlotrimazole, is a broad-spectrm [[azole]]-based antifungal drug sold under many trade names. It is used to treat vaginal yeast infections, oropharyngeal candidiasis, and fungal infections such as [[ringworm]], [[athlete's foot]] and [[jock itch]]. It is also used in combination with [[betamethasone]] in the treatment of cutaneous tinea infections. | ||
== Mechanisn of action == | |||
Like other azole-based antifungal drugs, clotrimazole increases cell permeability by interfering with the conversion of [[lanosterol]] to [[ergostol]], a critical component in fungal cell membranes, by inhibiting the enzyme [[14-alpha-methylase]], a P-450 enzyme. It is most effective against growing and dividing organisms. | |||
== Brand names == | == Brand names == | ||
Revision as of 10:24, 12 May 2008
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| clotrimazole | |||||||
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| Uses: | antifungal drug | ||||||
| Properties: | azole compound | ||||||
| Hazards: | see side effects & drug interactions | ||||||
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Clotrimazole, also called clotrimazol and chlotrimazole, is a broad-spectrm azole-based antifungal drug sold under many trade names. It is used to treat vaginal yeast infections, oropharyngeal candidiasis, and fungal infections such as ringworm, athlete's foot and jock itch. It is also used in combination with betamethasone in the treatment of cutaneous tinea infections.
Mechanisn of action
Like other azole-based antifungal drugs, clotrimazole increases cell permeability by interfering with the conversion of lanosterol to ergostol, a critical component in fungal cell membranes, by inhibiting the enzyme 14-alpha-methylase, a P-450 enzyme. It is most effective against growing and dividing organisms.
Brand names
Canesten® Canestine® Canifug® Cimitidine® Clotrimaderm® Empecid® FemCare® Gyne-Lotrimin 3® Gyne-Lotrimin® Gyne-Lotrimin ® Gynix® Lotrimin® Mono-baycuten Mycelax® Mycelex® Mycelex 7® Mycelex G ® Mycelex Troches® Mycelex-7® Myclo® Myclo-Gyne® Mycosporin® Mykosporin® Neo-Zol Cream® Trimysten® Trivagizole 3® Veltrim®