Talk:Hormesis: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>Howard C. Berkowitz
imported>Howard C. Berkowitz
Line 5: Line 5:
== Hoping this is a reasonable approach ==
== Hoping this is a reasonable approach ==


One of the first thing that hormesis brings to mind is type-0 and type-1 pharmacokinetics, especially drug (or toxin) clearance. Obviously simplified, zero-order kinetics has a basic model that the excretion process has infinite capacity, while first-order kinetics has a saturation point.  
One of the first thing that hormesis brings to mind is type-0 and type-1 pharmacokinetics, especially drug (or toxin) clearance. Obviously simplified, zero-order kinetics has a basic model that the excretion process has infinite capacity, while first-order kinetics has a saturation point. More precisely, zero-order kinetics asssume a constant absolute rate of clearance, while first-order clearance assumes a constant fraction of the total body concentraion over time.


Such effects are at the high-end range of dose-effect mechanisms.
Such effects are at the high-end range of dose-effect mechanisms.

Revision as of 12:00, 1 October 2008

This article is developing and not approved.
 Main Article
 Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
To learn how to update the categories for this article, see here. To update categories, edit the metadata template.
 Definition:  A quantitative and qualitative dose-response relationship in which the effect at low concentrations occurs in the opposite direction from that expected from the effect observed at higher concentrations. [d] [e]
Checklist and Archives
 Workgroup categories:  Health Sciences, Biology and Chemistry [Categories OK]
 Talk Archive:  none  English language variant:  American English

Starting article on "hormesis"

Encouraging collaboration.

Hoping this is a reasonable approach

One of the first thing that hormesis brings to mind is type-0 and type-1 pharmacokinetics, especially drug (or toxin) clearance. Obviously simplified, zero-order kinetics has a basic model that the excretion process has infinite capacity, while first-order kinetics has a saturation point. More precisely, zero-order kinetics asssume a constant absolute rate of clearance, while first-order clearance assumes a constant fraction of the total body concentraion over time.

Such effects are at the high-end range of dose-effect mechanisms.

At a low end -- thinking of infection rather than drugs -- in biohazard mitigation and biological warfare work, there is a well-established "minimum infective concentration" (often expressed as the 50th percentile). Tularemia, for example, can establish disease with only a few cells, where more dangerous agents require a considerably larger concenntration.

Howard C. Berkowitz 12:32, 1 October 2008 (CDT)

Retrieved from "https://citizendium.org/wiki/index.php?title=Talk:Hormesis&oldid=521107"