Atenolol: Difference between revisions
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In [[medicine]], '''atenolol''' is a cardioselective [[adrenergic beta-antagonist]] that is "possessing properties and potency similar to [[propranolol]], but without a negative inotropic effect."<ref>{{MeSH}}</ref> | In [[medicine]], '''atenolol''' is a cardioselective [[adrenergic beta-antagonist]] that is "possessing properties and potency similar to [[propranolol]], but without a negative inotropic effect."<ref>{{MeSH}}</ref> Atenolol is hydrophilic<ref name="pmid8521562">{{cite journal |author=Tuininga YS, Crijns HJ, Brouwer J, ''et al'' |title=Evaluation of importance of central effects of atenolol and metoprolol measured by heart rate variability during mental performance tasks, physical exercise, and daily life in stable postinfarct patients |journal=Circulation |volume=92 |issue=12 |pages=3415–23 |year=1995 |month=December |pmid=8521562 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=8521562 |issn=}}</ref> | ||
==Metabolism== | ==Metabolism== | ||
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==Dosage== | ==Dosage== | ||
For healthy adults, the starting dose is 50 mg orally once daily and the maximum dose is 100 mg orally once daily. | For healthy adults, the starting dose is 50 mg orally once daily and the maximum dose is 100 mg orally once daily. ''However'', atenolol may require twice daily dosing<ref name="pmid18259123">{{cite journal |author=Sarafidis P, Bogojevic Z, Basta E, Kirstner E, Bakris GL |title=Comparative efficacy of two different beta-blockers on 24-hour blood pressure control |journal=J Clin Hypertens (Greenwich) |volume=10 |issue=2 |pages=112–8 |year=2008 |month=February |pmid=18259123 |doi= |url= |issn=}}</ref> | ||
==External links== | ==External links== | ||
Revision as of 09:02, 7 January 2009
In medicine, atenolol is a cardioselective adrenergic beta-antagonist that is "possessing properties and potency similar to propranolol, but without a negative inotropic effect."[1] Atenolol is hydrophilic[2]
Metabolism
Atenolol is excreted unchanged in the kidneys. Elimination is dependent on the glomerular filtration rate. Atenolol is not metabolized in the liver by cytochrome P-450 2D6 allele.
Dosage
For healthy adults, the starting dose is 50 mg orally once daily and the maximum dose is 100 mg orally once daily. However, atenolol may require twice daily dosing[3]
External links
The most up-to-date information about Atenolol and other drugs can be found at the following sites.
- Atenolol - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Atenolol - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Atenolol - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Atenolol (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Tuininga YS, Crijns HJ, Brouwer J, et al (December 1995). "Evaluation of importance of central effects of atenolol and metoprolol measured by heart rate variability during mental performance tasks, physical exercise, and daily life in stable postinfarct patients". Circulation 92 (12): 3415–23. PMID 8521562. [e]
- ↑ Sarafidis P, Bogojevic Z, Basta E, Kirstner E, Bakris GL (February 2008). "Comparative efficacy of two different beta-blockers on 24-hour blood pressure control". J Clin Hypertens (Greenwich) 10 (2): 112–8. PMID 18259123. [e]