Steatohepatitis: Difference between revisions
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==Treatment== | ==Treatment== | ||
[[ | [[Vitamin E]], but not [[pioglitazone]], may improve liver histology in a [[randomized controlled trial]] of 247 patients who did not have [[diabetes]].<ref name="pmid17135584">{{cite journal| author=Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J et al.| title=A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. | journal=N Engl J Med | year= 2006 | volume= 355 | issue= 22 | pages= 2297-307 | pmid=17135584 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=17135584 | doi=10.1056/NEJMoa060326 }} | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=17135584 | doi=10.1056/NEJMoa060326 }} </ref> | ||
Previously, [[pioglitazone]], a [[thiazolidinedione]] derivative normally used for treating [[diabetes mellitus type 2]], can improve nonalcoholic steatohepatitis in patients with [[impaired glucose tolerance]] or [[diabetes mellitus type 2]] according to a preliminary [[randomized controlled trial]] of 55 patients.<ref name="pmid17135584">{{cite journal| author=Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J et al.| title=A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. | journal=N Engl J Med | year= 2006 | volume= 355 | issue= 22 | pages= 2297-307 | pmid=17135584 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=17135584 | doi=10.1056/NEJMoa060326 }}</ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 12:17, 29 April 2010
In medicine, steatohepatitis is a liver disease characterized by fatty liver and lobular hepatitis.[1]
Hepatitis, inflammation of the liver, can be detected by liver biopsy, or can be suggested by elevated blood levels of tumor necrosis factor - alpha (TNF-alpha) and transforming growth factor beta (TGF-beta).[2]
Classification
Alcoholic steatohepatitis
Nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is associated with obesity, diabetes mellitus, or hyperlipidemia.[1] NASH may be caused by the single-nucleotide polymorphisms rs2854116 (c.455T>C) and rs2854117 (c.482C>T) of apolipoprotein C-III which are also associated with insulin resistance and hypertriglyceridemia.[3]
Treatment
Vitamin E, but not pioglitazone, may improve liver histology in a randomized controlled trial of 247 patients who did not have diabetes.[2]
Previously, pioglitazone, a thiazolidinedione derivative normally used for treating diabetes mellitus type 2, can improve nonalcoholic steatohepatitis in patients with impaired glucose tolerance or diabetes mellitus type 2 according to a preliminary randomized controlled trial of 55 patients.[2]
References
- ↑ 1.0 1.1 Sheth SG, Gordon FD, Chopra S (1997). "Nonalcoholic steatohepatitis.". Ann Intern Med 126 (2): 137-45. PMID 9005748.
- ↑ 2.0 2.1 2.2 Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J et al. (2006). "A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.". N Engl J Med 355 (22): 2297-307. DOI:10.1056/NEJMoa060326. PMID 17135584. Research Blogging.
Cite error: Invalid
<ref>tag; name "pmid17135584" defined multiple times with different content Cite error: Invalid<ref>tag; name "pmid17135584" defined multiple times with different content - ↑ Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM et al. (2010). "Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.". N Engl J Med 362 (12): 1082-9. DOI:10.1056/NEJMoa0907295. PMID 20335584. Research Blogging.