Hyponatremia: Difference between revisions
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'''Hyponatremia''' is not a specific disease, but a laboratory determination associated with a variety of diseases, in which the level of [[sodium]] ion circulating in the blood is below normal; the normal range is 136-146 mEq/L. In general, the cause is a disturbance in the mechanisms of water excretion. Total body sodium may be normal, but the rato between sodium in the intracellular and extracellular components may be inappropriate. <ref>{{citation | |||
| contribution = Chapter 42, Fluid, Electrolyte, and Acid-Base Emergencies | |||
| author = Chansky ME, Nyce A, Friedman J | |||
| title = Current Emergency Diagnosis and Treatment | |||
| editor = Stone CK, Humphries CK | |||
| edition = Fifth Edition | |||
| publisher = Lange Medical Books, McGraw-Hill | |||
| year = 2004 | |||
}}</ref> | |||
==Diagnosis== | |||
The initial diagnosis of hyponatremia, as opposed to the underlying disorder, normally comes from a [[serum electrolyte panel]] taken from blood. Continuous monitoring, typically in the [[critical care]] environment, can come from an indwelling ion-selective electrode. | |||
Experienced physicians have difficulty in determining the underlying causes of hyponatremia.<ref name="pmid20609688">{{cite journal| author=Fenske W, Maier SK, Blechschmidt A, Allolio B, Störk S| title=Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study. | journal=Am J Med | year= 2010 | volume= 123 | issue= 7 | pages= 652-7 | pmid=20609688 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20609688 | doi=10.1016/j.amjmed.2010.01.013 }} </ref> | Experienced physicians have difficulty in determining the underlying causes of hyponatremia.<ref name="pmid20609688">{{cite journal| author=Fenske W, Maier SK, Blechschmidt A, Allolio B, Störk S| title=Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study. | journal=Am J Med | year= 2010 | volume= 123 | issue= 7 | pages= 652-7 | pmid=20609688 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20609688 | doi=10.1016/j.amjmed.2010.01.013 }} </ref> | ||
==Treatment== | ==Treatment== | ||
[[Tolvaptan]], a [[vasopressin]] receptor antagonist, can be used for | Immediate treatment includes water restriction, and often, but with care, [[diuretic]]s, usually [[furosemide]], along with isotonic (0.9%) sodium chloride solution (i.e., saline). Dialysis may be appropriate, especially in patients with renal failure. | ||
If the hyponatremic state is causing severe changes, such as coma or seizure, small amounts of hypertonic (3%) saline may be administered intravenously. Hypertonic saline generally is reserved for intensive care units, in which continuous monitoring of [[central venous pressure]] or [[pulmonary capillary wedge pressure]] is available. Furosemide is usually given with the saline. <ref>Chansky, Nyce & Friedman, p. 894</ref> | |||
[[Tolvaptan]], a [[vasopressin]] receptor antagonist, can be used for hyponatremia.<ref>(2009) [http://www.medicalletter.org/restricted/articles/w1326c.html Tolvaptan (Samsca) for Hyponatremia] The Medical Letter</ref><ref name="pmid20538391">{{cite journal| author=Rozen-Zvi B, Yahav D, Gheorghiade M, Korzets A, Leibovici L, Gafter U| title=Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis. | journal=Am J Kidney Dis | year= 2010 | volume= 56 | issue= 2 | pages= 325-37 | pmid=20538391 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20538391 | doi=10.1053/j.ajkd.2010.01.013 }}</ref> However, [[vasopressin]] receptor antagonist may increase the frequency of rapid sodium correction although [[osmotic demyelination syndrome]] may not be increased.<ref name="pmid20538391"/> | |||
==References== | ==References== | ||
{{reflist|2}} | |||
Revision as of 14:28, 18 September 2010
Hyponatremia is not a specific disease, but a laboratory determination associated with a variety of diseases, in which the level of sodium ion circulating in the blood is below normal; the normal range is 136-146 mEq/L. In general, the cause is a disturbance in the mechanisms of water excretion. Total body sodium may be normal, but the rato between sodium in the intracellular and extracellular components may be inappropriate. [1]
Diagnosis
The initial diagnosis of hyponatremia, as opposed to the underlying disorder, normally comes from a serum electrolyte panel taken from blood. Continuous monitoring, typically in the critical care environment, can come from an indwelling ion-selective electrode.
Experienced physicians have difficulty in determining the underlying causes of hyponatremia.[2]
Treatment
Immediate treatment includes water restriction, and often, but with care, diuretics, usually furosemide, along with isotonic (0.9%) sodium chloride solution (i.e., saline). Dialysis may be appropriate, especially in patients with renal failure.
If the hyponatremic state is causing severe changes, such as coma or seizure, small amounts of hypertonic (3%) saline may be administered intravenously. Hypertonic saline generally is reserved for intensive care units, in which continuous monitoring of central venous pressure or pulmonary capillary wedge pressure is available. Furosemide is usually given with the saline. [3]
Tolvaptan, a vasopressin receptor antagonist, can be used for hyponatremia.[4][5] However, vasopressin receptor antagonist may increase the frequency of rapid sodium correction although osmotic demyelination syndrome may not be increased.[5]
References
- ↑ Chansky ME, Nyce A, Friedman J (2004), Chapter 42, Fluid, Electrolyte, and Acid-Base Emergencies, in Stone CK, Humphries CK, Current Emergency Diagnosis and Treatment (Fifth Edition ed.), Lange Medical Books, McGraw-Hill
- ↑ Fenske W, Maier SK, Blechschmidt A, Allolio B, Störk S (2010). "Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study.". Am J Med 123 (7): 652-7. DOI:10.1016/j.amjmed.2010.01.013. PMID 20609688. Research Blogging.
- ↑ Chansky, Nyce & Friedman, p. 894
- ↑ (2009) Tolvaptan (Samsca) for Hyponatremia The Medical Letter
- ↑ 5.0 5.1 Rozen-Zvi B, Yahav D, Gheorghiade M, Korzets A, Leibovici L, Gafter U (2010). "Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis.". Am J Kidney Dis 56 (2): 325-37. DOI:10.1053/j.ajkd.2010.01.013. PMID 20538391. Research Blogging.