BRCA2 gene: Difference between revisions
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In [[physiology]], '''BRCA2 gene''' ('''BRCA-2 gene''') is "a [[tumor suppressor gene]] located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."<ref>{{MeSH}}</ref> | In [[physiology]], '''BRCA2 gene''' ('''BRCA-2 gene''') is "a [[tumor suppressor gene]] located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."<ref>{{MeSH}}</ref> | ||
Women who have [[BRCA1 gene| | Women who have [[BRCA1 gene|BRCA1]] or BRCA2 genes, especially if there is a familial history of [[breast cancer]], may be candidates for prophylactic [[mastectomy]]. <ref>{{citation | ||
| journal = J Natl Cancer Inst | | journal = J Natl Cancer Inst | ||
| volume 93 | issue = 21 | | volume 93 | issue = 21 | ||
Revision as of 21:02, 22 August 2010
In physiology, BRCA2 gene (BRCA-2 gene) is "a tumor suppressor gene located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."[1]
Women who have BRCA1 or BRCA2 genes, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]
References
- ↑ Anonymous (2024), BRCA2 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst (no. 21): 1633-1637