Lovastatin: Difference between revisions

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[[Image:Lovastatin structure.jpg|right|thumb|150px|{{#ifexist:Template:Lovastatin structure.jpg/credit|{{Lovastatin structure.jpg/credit}}<br/>|}}Lovastatin, a class I statin.]]  
[[Image:Lovastatin structure.jpg|right|thumb|150px|{{#ifexist:Template:Lovastatin structure.jpg/credit|{{Lovastatin structure.jpg/credit}}<br/>|}}Lovastatin, a type I statin.]]  


'''Lovastatin''', also known as '''lovastatina''' (Spanish),  '''lovastatine''' (French),  '''lovastatinum''' (Latin) and  6-alpha-methylcompactin, is a class I [[statin]] used to treat [[hypercholesterolemia]] (high cholesterol) and prevent [[myocardial infarction|heart attacks]] and strokes by diminishing coronary [[atherosclerosis]].  It functions by inhibiting [[3-hydroxy-3-methylglutaryl coenzyme A reductase]]. It is a pro-drug, which only becomes active after metabolism to the active form, the <math>\beta</math>-hydroxyacid, a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to [[mevalonate]]. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway of cholesterol.  It was the first drug in the class HMG-CoA reductase inhibitors class, and it is a fungal metabolite isolated from cultures of ''Aspergillus terreus''.
'''Lovastatin''', also known as '''lovastatina''' (Spanish),  '''lovastatine''' (French),  '''lovastatinum''' (Latin) and  6-alpha-methylcompactin, is a type I [[statin]] used to treat [[hypercholesterolemia]] (high cholesterol) and prevent [[myocardial infarction|heart attacks]] and strokes by diminishing coronary [[atherosclerosis]].  It functions by inhibiting [[3-hydroxy-3-methylglutaryl coenzyme A reductase]]. It is a pro-drug, which only becomes active after metabolism to the active form, the <math>\beta</math>-hydroxyacid, a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to [[mevalonate]]. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway of cholesterol.  It was the first drug in the class HMG-CoA reductase inhibitors class, and it is a fungal metabolite isolated from cultures of ''Aspergillus terreus''.


Its IUPAC name is [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,
Its IUPAC name is [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,

Revision as of 14:54, 24 January 2008

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(CC) Image: David E. Volk
Lovastatin, a type I statin.

Lovastatin, also known as lovastatina (Spanish), lovastatine (French), lovastatinum (Latin) and 6-alpha-methylcompactin, is a type I statin used to treat hypercholesterolemia (high cholesterol) and prevent heart attacks and strokes by diminishing coronary atherosclerosis. It functions by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase. It is a pro-drug, which only becomes active after metabolism to the active form, the -hydroxyacid, a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway of cholesterol. It was the first drug in the class HMG-CoA reductase inhibitors class, and it is a fungal metabolite isolated from cultures of Aspergillus terreus.

Its IUPAC name is [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2, 3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate and its chemical formula is C24H36O5.


Brand names

  • Altocor
  • Altoprev
  • Artein
  • Belvas
  • Cholestra
  • Closterol
  • Colevix
  • Hipolip
  • Hipovastin
  • Lestatin
  • Lipdip
  • Lipivas
  • Lipofren
  • Lovalip
  • Lovalord
  • Lovasterol
  • Lovastin
  • Lozutin
  • Mevacor
  • Mevinacor
  • Mevlor
  • Monacolin K
  • Nergadan
  • Paschol
  • Rodatin
  • Rovacor
  • Sivlor
  • Taucor
  • Tecnolip
  • Teroltrat

References


External links

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