Cidofovir: Difference between revisions
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{{Chem infobox | {{Chem infobox | ||
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|image= [[Image:Cidofovir structure.jpg| | |image= [[Image:Cidofovir structure.jpg|center|thumb|200px|{{#ifexist:Template:Cidofovir structure.jpg/credit|{{Cidofovir structure.jpg/credit}}<br/>|}}Cidofovir, a nucleoside analog used to treat HIV.]] | ||
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'''Cidofovir''' ('''CDV''') is an [[antiviral drug]] used to treat herpes [[cytomegalovirus]] (CMV) [[retinitis]] associated with [[HIV]]/[[AIDS]]. It is an analog of the natural nucleoside [[cytosine]] used in [[DNA]]. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. '''Warning''':''Acute renal failure requiring dialysis and/or contributing to death have occured with as few as one or two doses of cidofovir''. | '''Cidofovir''' ('''CDV''') is an [[antiviral drug]] used to treat herpes [[cytomegalovirus]] (CMV) [[retinitis]] associated with [[HIV]]/[[AIDS]]. It is an analog of the natural nucleoside [[cytosine]] used in [[DNA]]. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. '''Warning''':''Acute renal failure requiring dialysis and/or contributing to death have occured with as few as one or two doses of cidofovir''. | ||
== Chemistry == | == Chemistry == | ||
Revision as of 15:39, 26 March 2008
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| cidofovir | |||||||
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| Uses: | antiviral drug | ||||||
| Properties: | cytosine analog | ||||||
| Hazards: | renal failure | ||||||
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Cidofovir (CDV) is an antiviral drug used to treat herpes cytomegalovirus (CMV) retinitis associated with HIV/AIDS. It is an analog of the natural nucleoside cytosine used in DNA. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. Warning:Acute renal failure requiring dialysis and/or contributing to death have occured with as few as one or two doses of cidofovir.
Chemistry
Its chemical name is [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid and its chemical formula is C8H14N3O6P. It is sold under the brand names HPMPC and Vistide.
External Links
- Cidofovir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Template:MedMaster
- Template:DrugBank