Clotrimazole: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
mNo edit summary
imported>Milton Beychok
(Undo revision 100471695 by David E. Volk (Talk) Undid inadvertant deletion by David Volk)
Line 17: Line 17:


'''Clotrimazole''', also called clotrimazol and chlotrimazole, is a broad-spectrm [[azole]]-based antifungal drug sold under many trade names.  It is used to treat vaginal yeast infections, oropharyngeal candidiasis, and fungal infections such as [[ringworm]], [[athlete's foot]] and [[jock itch]].  It is also used in combination with [[betamethasone]] in the treatment of cutaneous tinea infections.
'''Clotrimazole''', also called clotrimazol and chlotrimazole, is a broad-spectrm [[azole]]-based antifungal drug sold under many trade names.  It is used to treat vaginal yeast infections, oropharyngeal candidiasis, and fungal infections such as [[ringworm]], [[athlete's foot]] and [[jock itch]].  It is also used in combination with [[betamethasone]] in the treatment of cutaneous tinea infections.
== Mechanism of action ==
Like other azole-based antifungal drugs, clotrimazole increases cell permeability by interfering with the conversion of [[lanosterol]] to [[ergostol]], a critical component in fungal cell membranes, by inhibiting the enzyme [[14-alpha-methylase]], a P-450 enzyme.  It is most effective against growing and dividing organisms.
== Brand names ==
* Canesten® 
* Canestine®
* Canifug®
* Cimitidine®
* Clotrimaderm®
* Empecid®
* FemCare®
* Gyne-Lotrimin 3®
* Gyne-Lotrimin®
* Gyne-Lotrimin ®
* Gynix®
* Lotrimin®
* Mono-baycuten
* Mycelax®
* Mycelex®
* Mycelex 7®
* Mycelex G ®
* Mycelex Troches®
* Mycelex-7®
* Myclo®
* Myclo-Gyne®
* Mycosporin®
* Mykosporin®
* Neo-Zol Cream®
* Trimysten®
* Trivagizole 3®
* Veltrim®
== References and external links ==
* {{DailyMed}}
* {{MedMaster}}
* {{DrugBank}}

Revision as of 11:19, 6 April 2009

This article is developing and not approved.
 Main Article
 Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
https://en.citizendium.org/wiki/index.php?title=Clotrimazole&printable=yes
This editable Main Article is under development and subject to a disclaimer.
Clotrimazole.jpg
clotrimazole
IUPAC name: 1-[(2-chlorophenyl)-di(phenyl)methyl]imidazole
Synonyms: clotrimazol, chlotrimazole
Formula: C22H17ClN2
 Uses: antifungal drug
 Properties: azole compound
 Hazards: see side effects & drug interactions
Mass (g/mol): CAS #:
344.8368 23593-75-1


Clotrimazole, also called clotrimazol and chlotrimazole, is a broad-spectrm azole-based antifungal drug sold under many trade names. It is used to treat vaginal yeast infections, oropharyngeal candidiasis, and fungal infections such as ringworm, athlete's foot and jock itch. It is also used in combination with betamethasone in the treatment of cutaneous tinea infections.

Mechanism of action

Like other azole-based antifungal drugs, clotrimazole increases cell permeability by interfering with the conversion of lanosterol to ergostol, a critical component in fungal cell membranes, by inhibiting the enzyme 14-alpha-methylase, a P-450 enzyme. It is most effective against growing and dividing organisms.

Brand names

  • Canesten®
  • Canestine®
  • Canifug®
  • Cimitidine®
  • Clotrimaderm®
  • Empecid®
  • FemCare®
  • Gyne-Lotrimin 3®
  • Gyne-Lotrimin®
  • Gyne-Lotrimin ®
  • Gynix®
  • Lotrimin®
  • Mono-baycuten
  • Mycelax®
  • Mycelex®
  • Mycelex 7®
  • Mycelex G ®
  • Mycelex Troches®
  • Mycelex-7®
  • Myclo®
  • Myclo-Gyne®
  • Mycosporin®
  • Mykosporin®
  • Neo-Zol Cream®
  • Trimysten®
  • Trivagizole 3®
  • Veltrim®

References and external links

Retrieved from "https://citizendium.org/wiki/index.php?title=Clotrimazole&oldid=466128"