BRCA1 gene: Difference between revisions
Jump to navigation
Jump to search
imported>Howard C. Berkowitz mNo edit summary |
imported>David E. Volk mNo edit summary |
||
| Line 3: | Line 3: | ||
In [[physiology]], '''BRCA1 gene''' ('''BRCA-1 gene''') is "a [[tumor suppressor gene]] located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."<ref>{{MeSH}}</ref> | In [[physiology]], '''BRCA1 gene''' ('''BRCA-1 gene''') is "a [[tumor suppressor gene]] located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."<ref>{{MeSH}}</ref> | ||
Women who have BRCA1 or [[BRCA2 gene]] | Women who have BRCA1 or [[BRCA2 gene]] mutations, especially if there is a familial history of [[breast cancer]], may be candidates for prophylactic [[mastectomy]]. <ref>{{citation | ||
| journal = J Natl Cancer Inst | | journal = J Natl Cancer Inst | ||
| volume=93 | issue = 21 | | volume=93 | issue = 21 | ||
Revision as of 10:57, 24 October 2010
In physiology, BRCA1 gene (BRCA-1 gene) is "a tumor suppressor gene located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."[1]
Women who have BRCA1 or BRCA2 gene mutations, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]
References
- ↑ Anonymous (2024), BRCA1 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst 93 (21): 1633-1637