Granulomatous polyangiitis: Difference between revisions
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imported>Howard C. Berkowitz (New page: {{subpages}} '''Wegener's granulomatosis''' is a vasculitis of medium and small arteries, including venules and arterioles. It produces granulomatous inflammation of the respiratory tr...) |
imported>Robert Badgett No edit summary |
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{{subpages}} | {{subpages}} | ||
'''Wegener's granulomatosis''' is a [[vasculitis]] of medium and small arteries, including venules and arterioles. It produces granulomatous inflammation of the respiratory tracts and necrotizing, pauci-immune glomerulonephritis. | '''Granulomatous polyangiitis''', formerly called '''Wegener's granulomatosis''', is a [[vasculitis]] of medium and small arteries, including venules and arterioles. It produces granulomatous inflammation of the respiratory tracts and necrotizing, pauci-immune glomerulonephritis. | ||
While it is considered a rare disease (3 cases per 100,000 people in the U.S.),<ref>{{citation | While it is considered a rare disease (3 cases per 100,000 people in the U.S.),<ref>{{citation | ||
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==Diagnosis== | ==Diagnosis== | ||
Almost all patients with Wegener's have the c-ANCA form of [[antineutrophil cytoplasmic antibodies]], but not vice versa. | Almost all patients with Wegener's have the c-ANCA form of [[antineutrophil cytoplasmic antibodies]], but not vice versa. | ||
==References== | |||
<references/> | |||
Revision as of 18:13, 25 July 2011
Granulomatous polyangiitis, formerly called Wegener's granulomatosis, is a vasculitis of medium and small arteries, including venules and arterioles. It produces granulomatous inflammation of the respiratory tracts and necrotizing, pauci-immune glomerulonephritis.
While it is considered a rare disease (3 cases per 100,000 people in the U.S.),[1] Wegener's is the most common cause of saddle nose deformity in USA (nose flattened due to destruction of nasal septum by granulomatous inflammation). It also has a high mortality rate if untreated.
Diagnosis
Almost all patients with Wegener's have the c-ANCA form of antineutrophil cytoplasmic antibodies, but not vice versa.
References
- ↑ Patricia J Papadopoulos and Robert John O'Brian (4 August 2009), "eMedicine Specialties > Rheumatology > Vasculitis >Wegener Granulomatosis: Overview", eMedicine