Mirtazapine
Mirtazapine is a second-generation antidepressant agent.
History
Remeron brand of mirtazapine was approved for Organon USA by the Food and Drug Administration in the United States with a New Drug Application (NDA) in 1996.[1] A generic version with a AB Therapeutic Equivalence Code was approved for Glenmark Generics with a Abbreviated New Drug Application (ANDA) in 2004.[2]
Effectiveness
"The clinical response of our patients underscores the usefulness of mirtazapine in the treatment of the comorbid symptoms of weight loss, insomnia, and anxiety". [3]
Pharmacology
Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA).[4]
Administration
Distribution
Metabolism
Excretion
Toxicity
Drug toxicity is similar to tricyclic antidepressants. [Amitriptyline]], mirtazapine, and paroxetine may case more weight gain than other antidepressents according to a meta-analysis.[5]
External links
The most up-to-date information about Mirtazapine and other drugs can be found at the following sites.
- Mirtazapine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Mirtazapine - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Mirtazapine - Detailed information from DrugBank.
References
- ↑ Anonymous. Drugs@FDA for FDA Application No. 020415. U S Food and Drug Administration
- ↑ Anonymous. Drugs@FDA for FDA Application No. 076119. U S Food and Drug Administration
- ↑ Raji MA, Brady SR (2001). "Mirtazapine for treatment of depression and comorbidities in Alzheimer disease.". Ann Pharmacother 35 (9): 1024-7. PMID 11573849. [e]
- ↑ Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R et al. (2011). "Mirtazapine versus other antidepressive agents for depression.". Cochrane Database Syst Rev 12: CD006528. DOI:10.1002/14651858.CD006528.pub2. PMID 22161405. Research Blogging.
- ↑ Serretti A, Mandelli L (2010). "Antidepressants and body weight: a comprehensive review and meta-analysis.". J Clin Psychiatry 71 (10): 1259-72. DOI:10.4088/JCP.09r05346blu. PMID 21062615. Research Blogging.