Macromolecules
The literal definition of the term macromolecule implies any large molecule. In the context of science and engineering, the term may be applied to conventional polymers and biopolymers (such as DNA) as well as non-polymeric molecules with large molecular mass such as lipids or macrocycles. However, other large networks of atoms, such as metallic covalent networks or fullerenes, are not generally described as macromolecules. The term macromolecule was coined by Nobel laureate Hermann Staudinger in the 1920s.
Usage
The use of the term macromolecule varies subtly from discipline to discipline. From the strict perspective of chemistry, a "molecule" is comprised of a number of atoms linked by covalent bonds. In biology and biochemistry, however, the term macromolecule may refer to aggregates of two or more macromolecules held together by intermolecular forces rather than covalent bonds but which do not readily dissociate. [1]
According to the recommended IUPAC definition the term macromolecule as used in polymer science refers only to a single molecule. For example, a single polymeric molecule is appropriately described as a "macromolecule" or "polymer molecule" rather than a "polymer", which suggests a substance composed of macromolecules. [2].