User talk:Pierre-Alain Gouanvic

Tasks: start a new article • add basic, wanted or requested articles • add definitions • add metadata • edit new pages

Welcome to the Citizendium! We hope you will contribute boldly and well. Here are pointers for a quick start, and see Getting Started for other helpful "startup" links, our help system and CZ:Home for the top menu of community pages. You can test out editing in the sandbox if you'd like. If you need help to get going, the forum is one option. That's also where we discuss policy and proposals. You can ask any user or the editors for help, too. Just put a note on their "talk" page. Again, welcome and have fun! --Larry Sanger 00:35, 17 August 2007 (CDT)

Interesting

Interesting bio on your userpage, Pierre. Nice to you around, and let me know if I can ever assist you with things around here. Stephen Ewen 16:51, 13 November 2007 (CST)

Welcome and thanks

I'm just spending some time this morning thanking the newer/returned people who have been doing work on the wiki lately. So, thanks, nice to have you here! --Larry Sanger 09:39, 17 November 2007 (CST)

good info

Hi Pierre, I just saw your discussion on Talk:Evidence-based medicine. That is a good analysis and good point that should be in the article. Why don't you see if you can squeeze it in somewhere. --D. Matt Innis 00:43, 18 November 2007 (CST)

Potassium

Pierre-Alain: Yes, the article needs a discussion of potassium and the metabolic syndrome. Thanks for starting and stimulating that topic. I haven't had a chance to look at Metabolic syndrome yet but will try to do so soon. --Anthony.Sebastian (Talk) 22:25, 22 November 2007 (CST)

I have been working intensely on the Vitamin C page and left the metabolic syndrome with many deficiencies... The reason why I put the MS article aside for a while?

Several competing definitions of metabolic syndrome are in use, and each is differently linked to the presence of insulin resistance. These definitions include that of the National Cholesterol Education Program (NCEP) Third Adult Treatment Panel (ATP III) (2), the International Diabetes Federation (IDF) (3), and the European Group for the Study of Insulin Resistance (EGIR) (4). The EGIR definition requires the presence of insulin resistance plus any two other metabolic traits; ATP III and IDF definitions require at least three metabolic traits but do not require the presence of insulin resistance. In studies of ATP III metabolic syndrome, as many as half of subjects do not have insulin resistance (5–7).

Impact of Insulin Resistance on Risk of Type 2 Diabetes and Cardiovascular Disease in People With Metabolic Syndrome. James B. Meigs & al, Diabetes Care 30:1219-1225, 2007.

I don't like that. This reminds me of some nightmares I went through as a terminologist. I think that I'll leave MS (and other "clusters" for that matter) for a while and focus on insulin (resistance), ascorbate, SOD, oxidative stress, magnesium, potassium, exercise, adipocyte, many other things, but mostly basic building blocks of knowledge.

I have read BMC Evol Biol. 2007 Apr 17;7:61. Evolutionary origins of insulin resistance: a behavioral switch hypothesis. Watve MG, Yajnik CS Very enlightening and challenging. Pierre-Alain Gouanvic 00:15, 23 November 2007 (CST)

I seriously consider the idea that the metabolic syndrome page should be a very concise page describing the current disagreement and pointing to related pages: insulin resistance, CHD, hypertension, etc. There might be no other way to be objective.

It seems more logical and ethical to cluster conditions in function of common pathophysiological features (magnesium, potassium deficiency, C-reactive protein, etc, etc.) than in function of power struggles between specialists fighting with statistics devoid of any underlying physiological meaning. Pierre-Alain Gouanvic 00:31, 23 November 2007 (CST)