Gentamicin
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Dosage
The Prins nomogram uses simplified once daily dosing with the dose adjusted for renal function.[1] Depending on the estimated creatinine clearance (CC) (Online calculator), the daily intravenous dose is:
- CC more than 80 ml/min - 4 mg/kg
- CC between 50 and 80 ml/min - 3.25 mg/kg
- CC between 30 and 50 ml/min - 2.5 mg/kg
- CC below 30 ml/min - 2 mg/kg
The older Hull and Sarubbi nomogram uses a loading dose followed by smaller maintenance doses depending on renal function.[2]
References
- ↑ Prins JM, Weverling GJ, de Blok K, van Ketel RJ, Speelman P (1996). "Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy". Antimicrob. Agents Chemother. 40 (11): 2494–9. PMID 8913452. [e] Full text at PubMed Central
- ↑ Hull JH, Sarubbi FA (1976). "Gentamicin serum concentrations: pharmacokinetic predictions". Ann. Intern. Med. 85 (2): 183–9. PMID 942138. [e] online