Astrocytoma
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In neurology and oncology, an 'astrocytoma is a neoplasm of the central nervous system, which originates in normal astrocytes. Under the 1993 World Health Association criteria, a glioblastoma can be considered a "high-grade" (Grade IV) astrocytoma; grade III anaplastic astrocytomas are also malignant. The lower-grade astrocytomas may progress to higher-grade [1]
| WHO designation | WHO grade | Kernohan grade | St. Anne/Mayo grade | St. Anne/Mayo criteria |
|---|---|---|---|---|
| pilocytic astrocytoma | I | I | excluded | |
| Astrocytoma | II | I, II | 1 or 2 | 1: No criteria fulfilled; 2: one criterian, usually nuclear atypia |
| Anaplastic | II | II, III | 3 | Two criteria: nuclear atypia and mitosis |
| Malignant astrocytoma and glioblastoma | IV | III, IV | 4 | Three or four; add necrosis |
References
- ↑ Stephen B. Tatter (2006), The new WHO Classification of Tumors affecting the Central Nervous System, Neurosurgical Service, Massachussetts General Hospital