Amanita muscaria

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Amanita muscaria
Scientific classification
Kingdom: Fungi Phylum: Basidiomycota Class: Agaricomycetes Order: Agaricales Family: Amanitaceae Genus: Amanita Species: A. muscaria
Binomial name
Amanita muscaria (L.) Lam.

Description and significance

Amanita muscaria, commonly known as the fly agaric, is a psychoactive fungus. Known as the fly agaric for its ability to kill houseflies when combined with milk. The reason for this is, flies are attracted to the milk because it is so sweet, when they drink the milk they feel the effects of the mushroom and begin to appear intoxicated. They fly into walls and windows or just faint and can be disposed. The common hallucinogenic compounds found in Amanita muscaria are ibotenic acid (α-amino-3-hydroxy-5-isoxazoleacetic acid) and muscimol (3-hydroxy-5-aminomethyl-1-isoxazole).

Gills of Amanita muscaria

It is a fairly large mushroom with a bright red cap that ranges from 8-20 cm in diameter. The white spots on the cap are remains of the universal veil, a membrane that covers the mushroom at a young age. A partial veil usually forms a skirt like ring on the upper region of the stalk. The stalk or stipe is white or cream in color ranging from 5-20 cm high and 1-2 cm wide. The gills are free or slightly attached and are white in color.

Distribution and habitat

The fly agaric mushroom grows in symbiosis with birch, pine, and fir. It can be found in regions of both hemispheres (Alaska, Siberia, Scandinavia, central Europe, North America, Australia, Mexico, the Philippines) and in other regions where the aforementioned trees are located. The fly agaric is also found in the form of fairy rings.

Pharmacology

Ibotenic acid structure

Muscimol structure

The two psychoactive agents fount in Amanita muscaria are Ibotenic acid and Muscimol. Muscarine was originally thought to be the active hallucinogenic ingredient in A. muscaria. It was later found by researchers in the mid 20th century that these effects were caused by Ibotenic acid and Muscimol. There is a much larger amount of Ibotenic acid than Muscimol in the fly agaric, however the Ibotenic acid is decarboxylated when dried out turning it into Muscimol, this provides the psychoactive effect. Other agents found in A. muscaria are Muscarine, Muscazone, Bufotenin (5-OH-DMT), l-hyoscayamine, stizolobinic acid, stizolobic acid, methyltetrahydrocarboline carboxylic acid.

Related species and varieties

A. muscaria var. formosa

Amanita muscaria var. formosa, the yellow-orange fly agaric mushroom. It is found in eastern North America, abundant in the Sierra Nevada region.

Amanita muscraia var. flavivolvata, a form of the red fly agaric mushroom. It is found in western North America, common in northern California.

Amanita pantherina, the Panther Amanita. It can be dark to light brown or tan to dull yellow in color. It is common in Pacific Northwest but rare in the East. It has the highest incident of poisoning in the Pacific Northwest due to its confusion with A. gemmata.

Amanita gemmata, the Gemmed Amanita. It is creamy to pale yellow or golden yellow in color. Found primarily on the west coast.

Amanita phalloides, the "Death Cap”. This mushroom is highly poisonous. Varies in color from olive-green, yellow-green to yellow, gray and brown. It can be found in North America and is said to have been imported with European oak trees. It is mycorrhizal with oak trees in the summer and fall. A. phalloides has also been found in Pennsylvania so exact range is unclear.

Symptoms

Anthough the fly agaric is not considered to be deadly, the ibotenic acid and muscimol produce a large range of symptoms. These symptoms include nausea, dizziness, euphoria, deep coma-like sleep, hallucinations, headaches, auditory and visual distortions, twitching and mood changes.

Current Research

Analysis of hallucinogenic constituents in Amanita mushrooms circulated in Japan

A study of the chemical analysis of Amanita mushrooms circulated in the drug market of Japan. Samples were obtained from “smoke shops” or via Internet in Japan. Species of mushroom used were A. muscaria and A. pantherina. Caps and stems were used to extract Ibotenic acid and Muscimol. Amounts of both substances were then measured for potency. It was found that when A. muscaria was dried out in the sun or with a heater, the amount of Muscimol was increased. This was due to the Ibotenic acid being decarboxylated to form Muscimol. It was speculated that A. muscaria sold in the drug market was dreid out in the sun or with a heater to increase hallucinogenic effects.

Using human volunteers, symptoms were as follows: hallucination, delirium, muscular spasm and sleep. It was determined that ingestion of 7-30g of A. muscaria caps or 4-5g of A. pantherina caps would be enough for central nervous effects.

Hallucinogens and dissociative agents naturally growing in the United States

This research studies plants and fungi that contain mind altering ingredients. They examine N,N-Dimethyltryptamine and reversible monoamine oxidase inhibitors, psilocybe species muchrooms, peyote, mescaline containing cacti, salvia divinorum, lysergic acid amide containing plants, Amanita muscaria and Amanita pantherina. The section on Amanita muscaria and Amanita pantherina focuses on their active hallucinogenic compounds of ibotenic acid, muscimol and muscazone. The effects of these have been said to be similar to the effects of alcohol. They can also cause hallucinations and illusions, slurred speech, seizure, severe nausea and vomiting, coma like sleep and persistent headaches.

Muscimol has effects in quantities of 6mg while ibotenic acid has effects when 30-60mg is consumed. This is due to the small quantity of ibotenic acid that is decarboxylated into muscimol, the remaining ibotenic acid is excreted through urine. A unique finding is that effects have occurred from drinking the urine of an individual who had ingested the mushrooms.

Beringian origins and cryptic speciation events in the fly agaric (Amanita muscaria)

To determine the historical dispersal patterns of Amanita muscaria, specimens were collected from arctic, boreal and humid temperate regions in Alaska. DNA sequences were obtained from the protein-coding beta-tubulin gene, internal transcribed spacer and large subunit regions of the ribosomal DNA repeat. Nest clade analyses were performed to show phylogenic history.

The findings confirmed that mushrooms from arctic, boreal and humid temperate regions occurred sympatrically in Alaska. All species shared two morphological characteristics with other species. This suggests that prior to their speciations, cap and wart-color were of different varieties in different mushrooms.

Coalescent analysis and nest clade analysis showed that A. muscaria probably evolved in the Siberian-Beringian region. They were able to expand their species to North America and Eurasia and adapted to a cooler climate in Beringia.