Anacetrapib
Jump to navigation
Jump to search
|
| |||||||
| anacetrapib | |||||||
| |||||||
| Uses: | cholesterol regulation | ||||||
| Properties: | see below | ||||||
| Hazards: | see below | ||||||
| |||||||
In health care, anacetrapib (anacet'rapib) is an oxazolidinone-based medication that is a cholesteryl ester transfer protein inhibitor that raises HDL cholesterol and reduces LDL cholesterol.[1]
Anacetrapib is related to torcetrapib.[2]
Chemistry and Mechanism of Action
The chemical name of anacetrapib, distributed by Merck, is 2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one. It has a formula weight of 637.51 g/mol and its CAS registration number is 875446-37-0. Anacetrapib is an inhibitor of cholesteryl ester transfer protein (CETP), a key protein involved in reverse cholesterol transport, and its use increases high-density lipoprotein cholesterol (HDL). Other CETP inhibitors include dalcetrapib and torcetrapib. [3],[4]
References
- ↑ Anonymous (2024), Anacetrapib (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Cannon CP, Shah S, Dansky HM, Davidson M, Brinton EA, Gotto AM et al. (2010). "Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease.". N Engl J Med. DOI:10.1056/NEJMoa1009744. PMID 21082868. Research Blogging.
- ↑ Gurfinkel R, Joy TR (2010). "Anacetrapib: Hope for CETP Inhibitors". Cardiovasc Ther. PMID 21082868. [e]
- ↑ Mason D (2009). "Anacetrapib, a cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclrerosis". Curr Opin Investig Drugs 10 (9): 980-987. PMID 19705341. [e]